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Dynamics of healthcare-associated SARS-CoV-2 infections revealed with whole genome sequencing


Outbreaks of the coronavirus disease 2019 (COVID-19) are a frequent occurrence in healthcare settings such as hospitals and nursing homes, as physical distancing is difficult to achieve despite all infection prevention and control measures that are implemented in these settings. Early case detection allows individuals to be isolated and secondary transmissions better prevented, though pre- or asymptomatic cases that may still be transmitted between both healthcare workers and patients must also be considered.

In a paper recently published in the journal Infection Control & Hospital Epidemiology , the researchers study the dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on a geriatric hospital ward by whole genome sequencing. Herein, the researchers find the considerable secondary transmission to occur between patients and healthcare workers.

Unexpected details regarding nosocomial transmission revealed by whole-genome sequencing of severe acute respiratory syndrome coronavirus 2 Study: . Image Credit: tele52 / Evidence of nosocomial transmission

Individuals who tested positive for SARS-CoV-2 by reverse-transcriptase polymerase chain reaction (RT-PCR) assay of nasopharyngeal samples collected on a 30-bed hospital ward in Sweden over a one-month period were included in the study. Taken together, this included 32 patients and 15 healthcare workers.

The median age of patients […]

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